Fort Defiance
is really Trans-Allegheny Lunatic Asylum, Weston, WV
Real place, reimagined
Real-world photo: Wikimedia Commons
In the game
The Brotherhood of Steel's old headquarters, in a huge stone building.
The real place
A vast 19th-century asylum, the developers' most photographed stop while scouting West Virginia.
Visiting
History tours run by day and ghost tours by night.